Just as the title suggests? which do you prefer?
I was spraying neem and just switched to serenade. But thinking of still using the neem too.
Depends what you want to use it for.
Also, is the "problem" serious enough to use chemicals?
What pest or disease do you have? You need a product that addresses the specific problem.
You can use them both, for different things. Serenade I use for bacterial and fungal, and Neem I typically use for insects but also powdery mildew & BSM.